期刊
ACS NANO
卷 10, 期 1, 页码 499-506出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b05438
关键词
nanobiotechnology; fluorescence; optical biophysics; near-infrared sensors; in vivo spectroscopy; live cell measurements
类别
资金
- NIH [DP2-HD075698]
- Honorable Tina Brozman Foundation for Ovarian Cancer Research
- Louis V. Gerstner Jr. Young Investigator's Fund
- Frank A. Howard Scholars Program
- Cycle for Survival
- Alan and Sandra Gerry Metastasis Research Initiative
- MSKCC Center for Molecular Imaging and Nanotechnology
- Commonwealth Foundation for Cancer Research
- Experimental Therapeutics Center of Memorial Sloan-Kettering Cancer Center
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
- American Cancer Society
Cell adhesion is a protein-mediated process intrinsic to most living organisms. Dysfunction in cell adhesion processes is implicated in various diseases, including thrombosis and metastatic cancers. Using an approach to resolve spectral features from cell membrane-associated photoluminescent single-walled carbon nanotubes, we found that nanotube optical bandgaps respond to the electrostatic potential of the cell surface, which corresponds to cell adhesion properties. We studied the carbon nanotube emission energy response to solution ionic potentials, which suggests sensitivity to local charge accumulation. We conclude that nanotubes respond to cell surface electrostatic potentials that are mediated by membrane proteins, which vary significantly across cell types. These findings portend the optical measurement of surface electrostatic potentials for biophysical measurements and biomedical applications.
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