期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 427, 期 4, 页码 753-755出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2014.12.018
关键词
translation; antibiotic; P-site; tRNA
资金
- UK Medical Research Council [MC_U105184332]
- Wellcome Trust (Senior Investigator Award) [WT096570]
- Agouron Institute
- Jeantet Foundation
- United States Public Health Service Grant [GM-59026]
- National Science Foundation [DBI-0939454]
- Human Frontiers Science Program
- Medical Research Council [MC_U105184332] Funding Source: researchfish
- Wellcome Trust [096570/Z/11/Z] Funding Source: researchfish
- MRC [MC_U105184332] Funding Source: UKRI
The ribosome is the target of a large number of antibiotics. Here, we report a 3.4-angstrom-resolution crystal structure of bactobolin A bound to 70S ribosome-tRNA complex. The antibiotic binds at a previously unseen site in the 50S subunit and displaces tRNA bound at the P-site. It thus likely has a similar mechanism of action as blasticidin S despite binding to a different site. The structure also rationalizes previously identified resistance mutations. (C) 2015 The Authors. Published by Elsevier Ltd.
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