期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 427, 期 6, 页码 1135-1158出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2015.02.001
关键词
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资金
- Max Planck Society
- Max Planck Institute of Biochemistry, Martinsried, Germany
Mitochondria are the central hub of key cellular processes such as energy conversion, cell signaling, cell cycle regulation and cell differentiation. Therefore, in particular, mitochondrial biogenesis and protein translocation have been the focus of intense research for now nearly half a century. In spite of remarkable progress the field has made, many of the proposed mechanisms remain controversial and none of the translocation pathways is yet understood at the high-resolution level. In this context, the present article is intended to identify and discuss current major open questions and unresolved issues in the field in hope that it will stimulate and engage the pursuit of current efforts and expose new directions. (C) 2015 Published by Elsevier Ltd.
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