期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 78, 期 -, 页码 142-153出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2014.08.015
关键词
Mitochondrial permeability transition pore, MPTP; Permeability transition pore, PTP; Cell death; Apoptosis; Necrosis; Ischemia reperfusion injury
资金
- Italian Association for Cancer Research [AIRC: IG-14442, MFAG-13521]
- University of Ferrara to Paolo Pinton and Carlotta Giorgi
- Telethon [GGP11139B]
- Italian Ministry of Education, University and Research (COFIN, FIRB, and Futuro in Ricerca)
- Polish Ministry of Science and Higher Education [W100/HFSC/2011]
- HFSP [RGP0027/2011]
The mitochondrial permeability transition is a key event in cell death. Intense research efforts have been focused on elucidating the molecular components of the mitochondrial permeability transition pore (mPTP) to improve the understanding and treatment of various pathologies, including neurodegenerative disorders, cancer and cardiac diseases. Several molecular factors have been proposed as core components of the mPTP; however, further investigation has indicated that these factors are among a wide range of regulators. Thus, the scientific community lacks a clear model of the mPTP. Here, we review the molecular factors involved in the regulation and formation of the mPTP. Furthermore, we propose that the mitochondrial ATP synthase, specifically its c subunit, is the central core component of the mPTP complex. Moreover, we discuss the involvement of the mPTP in ischemia and reperfusion as well as the results of clinical studies targeting the mPTP to ameliorate ischemia-reperfusion injury. This article is part of a Special Issue entitled Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease. (C) 2014 Elsevier Ltd. All rights reserved.
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