Cardiac aging - Getting to the stem of the problem

Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the stem cell hypothesis of aging and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'. (C) 2015 Elsevier Ltd. All rights reserved.