期刊
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
卷 34, 期 5, 页码 404-413出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compmedimag.2010.02.001
关键词
Computerized method; Detection of multiple sclerosis; False positive reduction scheme; Rule-based method; Level set method; Support vector machine
The purpose of this study was to develop a computerized method for detection of multiple sclerosis (MS) lesions in brain magnetic resonance (MR) images. We have proposed a new false positive reduction scheme, which consisted of a rule-based method, a level set method, and a support vector machine. We applied the proposed method to 49 slices selected from 6 studies of three MS cases including 168 MS lesions. As a result, the sensitivity for detection of MS lesions was 81.5% with 2.9 false positives per slice based on a leave-one-candidate-out test, and the similarity index between MS regions determined by the proposed method and neuroradiologists was 0.768 on average. These results indicate the proposed method would be useful for assisting neuroradiologists in assessing the MS in clinical practice. (C) 2010 Elsevier Ltd. All rights reserved.
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