期刊
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
卷 14, 期 8, 页码 729-739出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10255842.2010.493522
关键词
lumbar spine; spine biomechanics; disc degeneration; finite element; poroelastic; intradiscal pressure
资金
- EU [HEALTH-F2-2008-201626]
Intervertebral disc degeneration involves changes in the spinal anatomical structures. The mechanical relevance of the following changes was investigated: disc height, endplate sclerosis, disc water content, permeability and depressurisation. A poroelastic nonlinear finite element model of the L4-L5 human spine segments was employed. Loads represented a daily cycle (500N compression combined with flexion-extension motion for 16 h followed by 200N compression for 8 h). In non-degenerative conditions, the model predicted a diurnal axial displacement of 1.32mm and a peak intradiscal pressure of 0.47 MPa. Axial displacement, facet force and range of motion in flexion-extension are decreased by decreasing disc height. By decreasing the initial water content, axial displacement, facet force and fluid loss were all reduced. Endplate sclerosis did not have a significant influence on the calculated results. Depressurisation determined an increase of the disc effective stress, possibly inducing failure. Degenerative instability was not calculated in any simulations.
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