期刊
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
卷 108, 期 3, 页码 1149-1159出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2012.08.004
关键词
Central corneal thickness; Glaucoma; Non-linear multivariable regression model; Heidelberg Retina Tomograph II
The present research investigates the relationship between the central corneal thickness (CCT), Heidelberg Retina Tomograph II (HRTII) structural measurements and intraocular pressure (IOP) using an innovative non-linear multivariable regression method in order to define the risk factors in future glaucoma development and patient management. The method is implemented to data from ninety-three open angle glaucoma eyes. The results show that in established glaucoma, CCT is significantly associated with HRTII structural measurements (maximum contour depression, cup volume inferotemporally) and IOP. They are also compared to those obtained from the application of standard linear regression methods, improving the coefficient determination R-2 by 35%, exhibiting thus the performance of the proposed methodology. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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