期刊
COMPUTATIONAL STATISTICS & DATA ANALYSIS
卷 52, 期 11, 页码 4989-4997出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.csda.2008.04.009
关键词
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Many generalizations of the Cox proportional hazard method have been elaborated to analyse recurrent event data. The Andersen-Gill model was proposed to handle event data following Poisson processes. This method is compared with non-survival approaches, such as Poisson and negative binomial regression. The comparison is performed on data simulated according to various event-generating processes and differing in subject heterogeneity. When robust standard error estimates are applied, for Poisson processes the Andersen-Gill approach is comparable to a negative binomial regression, whereas the poisson regression has comparable coverage probabilities of confidence intervals, but increased type I error rates; however, none of the methods can generate unbiased parameter estimates with data violating the independent increment assumption. These findings are illustrated by data from a clinical trial of the efficacy of a new pneumococcal vaccine for prevention of otitis media. (C) 2008 Elsevier B.V. All rights reserved.
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