期刊
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
卷 25, 期 6, 页码 946-950出版社
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.1412.12023
关键词
Mycobacterium tuberculosis; tamoxifen; intracellular killing; MDR; XDR
资金
- Ministry of Health & Welfare R&D Project, Republic of Korea [HI13C0828]
Recently, it has become a struggle to treat tuberculosis with the current commercial anti-tuberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the anti-mycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drug-sensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had anti-tuberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 mu g/ml) as well as drug-resistant strains (MIC, 6.25 to 12.5 mu g/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据