期刊
COMPTES RENDUS CHIMIE
卷 17, 期 5, 页码 484-489出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2013.08.007
关键词
p-Toluenesulfonic acid; 1,4-Dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidines; Solvent-free reaction; 2-Aminobenzimidazole; Malononitrile
资金
- second stage of BK21 Program
A simple, efficient, and green procedure for the preparation of 2-amino-4-substituted-1,4-dihydrobenzolo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitriles has been developed by multi-component condensation of 2-aminobenzimidazole with aldehydes and malononitrile in the presence of a catalytic amount of p-toluenesulfonic acid, affording excellent yields under neat conditions. The protocol avoids the use of expensive catalysts, toxic solvents, and chromatographic separation. We believe that this new environmentally metal-free procedure, combined to a solvent-free reaction, would be of importance in the search of green laboratory-scale synthesis. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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