One-pot multicomponent synthesis hexahydroquinoline derivatives in Triton X-100 aqueous micellar media

A facile and efficient synthesis of hexahydroquinoline derivatives (5a-o) was reported via a four-component condensation reaction of aldehydes, dimedone, methyl aceto acetate and ammonium acetate in the presence of Triton X-100 in water at room temperature. The use of just 20 mol % of Triton X-100 in water solvent is sufficient. The FT-IR, F-19 NMR, H-1 NMR, C-13 NMR spectra and elemental analysis confirm the structure of the compounds. (c) 2012 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.