期刊
COMPTES RENDUS CHIMIE
卷 16, 期 11, 页码 997-1001出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2013.05.002
关键词
Xanthene; Tetraketone; Deep eutectic solvent; Choline chloride; Active methylene compounds; Aldehyde; Chemoselectivity
资金
- Chemistry and Chemical Engineering Center of Iran
A chemoselective synthesis of tetraketone and xanthene derivatives, by means of tandem Knoevenagel condensation and Michael addition in choline chloride-based deep eutectic solvents (DESs), is presented. The reaction of readily available aldehydes and active methylene compounds in malonic acid- and ZnCl2-based DES gives various xanthenes derivatives with good to excellent yields under mild reaction conditions. On the other hand, tetraketones were synthesized in almost quantitative yields by simple condensation of an aldehyde and active methylene compounds in milder deep eutectic solvents of urea and SnCl2. In addition, the reaction of other types of choline chloride-based DES leads to a mixture of tetraketone and xanthene. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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