期刊
COMPTES RENDUS CHIMIE
卷 16, 期 5, 页码 419-426出版社
ACAD SCIENCES
DOI: 10.1016/j.crci.2012.11.018
关键词
Pyrans; MCRs; Amberlyst A21; Green synthesis
资金
- University Grants Commission-Special Assistance Programme (UGC-SAP), North Eastern Hill University, Shillong
Amberlyst A21, a neutral ion-exchange resin and a solid base, can catalyze the three-component reaction of aldehyde and malononitrile with various active methylene compounds at room temperature to synthesize a range of pharmaceutically important pyran annulated heterocycles. Use of the solid base could generate a highly green protocol by eliminating chromatographic purification that involves hazardous organic solvents, and facilitate easy recovery and reusability of the catalyst. (C) 2012 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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