期刊
COMPTES RENDUS CHIMIE
卷 13, 期 1-2, 页码 199-206出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2009.04.001
关键词
SBA-15; KIT-6; Affinity chromatography support; Mesoporous silica
资金
- FP6
Mesoporous silica supports are proposed as an alternative to polymeric stationary phases for fast affinity chromatography due to their better mechanical strength compared to polymers Ideal supports should combine high surface area and large pore size to allow a high loading capacity of large molecules, such as proteins, and favor their accessibility Increasing the pore size of large-surface area micelle-templated silicas (SBA-15, KIT-6) has been achieved by swelling the micelles by the addition of organic molecules and increasing synthesis lime and temperature. The pore size of hexagonal silica mesostructured SBA-15 has been increased up to 35 nm These materials could find therefore application as affinity chromatography for immunoextraction To cite this article: N. Calin et al., C. R. Chimie 13 (2010). (C) 2009 Published by Elsevier Masson SAS on behalf of Academic des sciences
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