期刊
COMPOSITE INTERFACES
卷 26, 期 5, 页码 465-478出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09276440.2018.1508266
关键词
Scaffold; 3D printing; entrapment; chitosan; surface modification; simulated body fluid; polylactic acid (PLA)
资金
- Key Research and Development Program of Shandong Province [2017GSF18157]
- Natural Science Foundation of Shandong Province [ZR2016HP39]
- UTM Collaborative Research Grant Scheme [PY/2017/02206]
This work reports the surface modification of 3D printed PLA scaffold with chitosan and its hydroxyapatite (HA) forming capability. PLA scaffold was fabricated using a desktop 3D printer followed by the inclusion of chitosan on the surface via surface entrapment. Confocal laser scanning microscopy (CLSM) images showed existence of chitosan entrapment with depth of 24 mu m. Immersion of the modified PLA scaffold in simulated body fluid resulted in formation of apatite layers on the surface. Plus the entrapment method does not induce any cytotoxic response towards human fibroblast cell. This method provides a facile approach of obtaining 3D printed scaffold with good bioactivity thus has potential in biomimetic and tissue engineering. [GRAPHICS]
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