A case series on the use of lavendula oil capsules in patients suffering from major depressive disorder and symptoms of psychomotor agitation, insomnia and anxiety

Objective: Symptoms of agitation, anxiety and insomnia are frequent among patients with major depressive disorder (MDD) during the first weeks of psychiatric care. But a substantial number of patients declines taking pharmaceutical medication to avoid side effects. Therefore, an alternative herbal medication is needed. Clinical studies demonstrated that lavender oil capsules, termed Lasea (R), have an anxiolytic effect comparable to Lorazepam and significantly reduce insomnia and agitation in non-depressed patients. Therefore, the aim of this retrospective case series was to analyze the effectiveness of Lasea (R) for patients with MDD and symptoms of anxiety, insomnia and psychomotor agitation. Design: Eight cases were analyzed retrospectively regarding the dosage, length of treatment, possible side effects and effectiveness of Lasea (R). Setting: All cases were treated at the Department of Psychiatry at Charite - Universitatsmedizin Berlin, Campus Benjamin Franklin in a naturalistic setting. Main outcome measure: Effectiveness was measured by a change in the Hamilton Rating Scale for Depression (HAMD-17) total score and subscores. Results: In 6 cases, the combination of Lasea (R) and an antidepressant resulted in a reduction of MDD. Lasea (R) also reduced agitation in 6 cases. Psychological anxiety was reduced in 5, somatic anxiety in 4 cases whereas sleep-onset and sleep-maintenance insomnia improved in 3 cases each. Conclusions: The results demonstrate that Lasea (R) reduces some of the anxiety related symptoms and sleep disturbances in MDD patients. Furthermore Lasea (R) significantly reduces psychomotor agitation. Additionally, the results indicate a significant global improvement stemming from the combinational therapy of Lasea (R) and antidepressant medication. (C) 2013 Elsevier Ltd. All rights reserved.