期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 58, 期 13, 页码 5226-5241出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.5b00651
关键词
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资金
- CSIR, New Delhi [CSC0302, CSC0111]
- Ramanujan Fellowship Grant [SR/S2/RJN 04/2010, GAP0305]
- DST, New Delhi
- UGC, New Delhi
A series of four new mononuclear copper(II) polypyridyl complexes (1-4) have been designed, developed, and thoroughly characterized by several physicochemical techniques. The CT-DNA binding properties of 1-4 have been investigated by absorption, emission spectroscopy, and viscosity measurements. All the complexes especially 1 and 4 exhibit cytotoxicity toward several cancer cell lines, suggesting their anticancer properties as observed by several in vitro assays. Additionally, the complexes show inhibition of endothelial cell (HUVECs) proliferation, indicating their antiangiogenic nature. In vivo chick embryo angiogenesis assay again confirms the antiangiogenic properties of 1 and 4. The formation of excessive intracellular ROS (H2O2 and O-2(center dot-))) and upregulation of BAX induced by copper(II) complexes may be the plausible mechanisms behind their anticancer activities. The present study may offer a basis for the development of new transition metal complexes through suitable choice of ligands for cancer therapeutics by controlling tumor angiogenesis.
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