期刊
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
卷 34, 期 5, 页码 419-427出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cimid.2011.07.003
关键词
Hepatitis E; Pig; Animal reservoir; Zoonosis; Public health
资金
- Agence Nationale de la Recherche [PNRA07-008 HEVEZOONEPI]
The importance of the domestic pig reservoir for Hepatitis E virus (HEV) was assessed by estimating the seroprevalence and prevalence of HEV contaminated livers in French slaughter-aged pigs. 6565 sera and 3715 livers were randomly sampled from 186 pig farms throughout the country. Taking the sampling design into account, the farm-level seroprevalence was 65% (95% CI 57-74) and 31% (95% CI 24-38) of the slaughter-aged pigs had antibodies against HEV. The individual prevalence of HEV RNA positive livers was 4% (95% CI 2-6) and 24% (95% CI 17-31) of the farms had at least 1 positive liver. Most isolates were of genotype 3f (76.7%) with smaller amounts of 3c (18.6%) and 3e (4.6%). The high prevalence of HEV in pigs and the similarities between HEV subtypes from pigs and humans corroborates the possible zoonotic origin of some HEV autochthonous infections. (C) 2011 Elsevier Ltd. All rights reserved.
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