期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷 214, 期 -, 页码 17-22出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2018.08.003
关键词
Standard metabolism; Mitochondria metabolism; Waterborne cadmium exposure; Metabolism adjustment; Silurus meridionalis
资金
- Natural Science Foundation of Chongqing [cstc2013jjB80008]
- Fundamental Research Funds for the Central Universities [XDJK2016C156]
- Start-up Research Grant from Qinzhou University [2017KYQD107]
- Research Funds Guangxi Key Laboratory of Beibu Gulf Marine Biodiversity Conservation [2018ZB03]
- Project of Basic Ability Improvement of Young and Middle-aged Teachers of Universities in Guangxi [2018KY0623]
We investigated the standard metabolic rate and liver mitochondria metabolism of the southern catfish when exposed to waterborne cadmium. Juvenile southern catfish were exposed to waterborne cadmium concentrations (0, 62.5, 125, 250 and 500 mu g/L, respectively) for 8 weeks, and the final body mass, the standard metabolic rate, the state III respiration rate, the activity of cytochrome C oxidase (CCO) of liver mitochondria, and the hepatosomatic index (HSI) were determined. The results showed that the 62.5 mu g/L, 125 mu g/L, and 250 mu g/L experiment groups had a significantly higher standard metabolic rate than that of the control group. Standard metabolic rate in the 500 mu g/L experiment group did not differ from the control group. State III respiration rate of liver mitochondria decreased with an increase in cadmium concentration. The 125 mu g/L, 250 mu g/L, and 500 mu g/L experiment groups had a significantly lower state III respiration rate than that of the control group. The activity of CCO in the 500 mu g/L experiment group was significantly lower than that of the control group. These results suggest that at low cadmium concentrations, the southern catfish could continuously improve the standard metabolism to provide extra energy in response to the cadmium stress. Cadmium exposures caused damage to the structure and function of liver mitochondria and decreased the activity of mitochondria enzymes, which results in a decrease in the energy of the liver metabolism. The adjustment of the metabolism of liver mitochondria in southern catfish was inconsistent with the adjustment of individual standard metabolism.
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