期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷 154, 期 1, 页码 56-63出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2011.02.004
关键词
Binary mixtures; Copper; Benzo(a)pyrene; Mussels; Antioxidant system
资金
- FCT (Foundation for Science and Technology) [SFRH/BPD/26970/2006]
- CIMA Technology
- Sciences Faculty
- University of Algarve
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/26970/2006] Funding Source: FCT
This study aimed to assess the antioxidant system potential and lipid peroxidative effects, in the gill and digestive gland of Mytilus galloprovincialis exposed to individual and binary mixtures of benzo(a)pyrene (BaP) and Cu for 7 days. Data demonstrated that in mussels exposed to BaP antioxidant enzymes (catalase - CAT, total glutathione peroxidase - tGPx, glutathione S-transferase - GST and glutathione reductase - GR) and lipid peroxidation (LPO) increased in the gill. On the contrary, in the digestive gland inhibitory antioxidant effects (superoxide dismutase-SOD, GR, metallothioneins-MT) and no changes in LPO levels were detected. Cu was also a potent oxidant agent since MT and LPO levels increased in mussel gill, despite no LPO effect in the digestive gland. For both single contaminants the organ specificity and distinct physiologic/metabolism roles were evident in terms of antioxidant capacity. Gill SOD inhibition, MT and GST unchanged was a result of simple independent action of exposure to BaP and Cu. Interactions in the binary mixtures, led to absence of changes in LPO effects. In the digestive gland, BaP and Cu interactions were also responsible for the GST and LPO enhancement (antagonistic effects). The current findings demonstrate the differences in antioxidant responses where the organ dependency highlights each contaminant particular mode of action. Generally, in the gill non-interactive effects occurred with the lowest Cu concentration while interactions exist for the mixture with the highest Cu concentrations. In the digestive gland, interactions and no interaction effects occurred in all the binary mixtures. Complex contaminant mixtures interact differently based on target tissue which may lead to an imbalance in the mussels health status. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据