期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 58, 期 3, 页码 1400-1419出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm501722s
关键词
-
资金
- Agency for Science Technology and Research (A*STAR) [1021490113]
- Hungarian Office of Science and Technology [TET_10-1-2011-0050]
To develop novel neuroprotective agents, a library of novel arylalkenylpropargylamines was synthesized and tested for inhibitory activities against monoamine oxidases. From this, a number of highly potent and selective monoamine oxidase B inhibitors were identified. Selected compounds were also tested for neuroprotection in in vitro studies with PC-12 cells treated with 6-OHDA and rotenone, respectively. It was observed that some of the compounds tested yielded a marked increase in survival in PC-12 cells treated with the neurotoxins. This indicates that these propargylamines are able to confer protection against the effects of the toxins and may also be considered as novel disease-modifying anti-Parkinsonian agents, which are much needed for the therapy of Parkinson's disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据