期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
卷 149, 期 1, 页码 44-50出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpa.2007.10.006
关键词
Bmall; circadian; entrainment; phase dependence; pacemaker; clock
The chicken pineal gland possesses the capacity to generate circadian oscillations, is able to synchronize to external light:dark cycles and can generate an hormonal output - melatonin. We examined the light responses of the chicken pineal gland and its effects on melatonin and Per2, Bmall and E4bT4 expression in 19-day old embryos and hatchlings during the dark, phase, subjective light phase and in constant darkness. Expression of Per2 and E4bp4 were rhythmic under light:dark conditions, but the rhythms of E4bp4 and Bmall mRNA did not persist in constant darkness in 19-day old embryos. Per2 rnRNA expression persisted in constant darkness, but with a reduced amplitude. Per2 expression was inducible by light only during the subjective day. Melatonin release was inhibited by light only at end of the dark phase and during the subjective light phase in embryos. Our data demonstrate that the embryonic avian pineal pacemaker is light sensitive and can generate rhythmic output, however the effects of light were diminished in chick embryos in compared to hatchlings. (C) 2007 Elsevier Inc. All rights reserved.
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