期刊
JOURNAL OF MEDICAL VIROLOGY
卷 88, 期 4, 页码 681-685出版社
WILEY
DOI: 10.1002/jmv.24374
关键词
hepatitis E virus; cross-species transmission; zoonosis; swine; rabbit
类别
资金
- National Science Foundation of China [81271827]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120001110098]
Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross-species transmission of sHEV to rabbits, the pigs with HEV infection were farmed along with SPF rabbits in the same enclosed space. Five of 10 rabbits had seroconversion for anti-HEV antibody from the third week after mix-breeding. However, HEV RNA remained undetectable in feces, serum, liver and bile of the ten rabbits; and no obvious elevation of ALT was observed. The results possibly suggested that sHEV might lead to an inapparent infection of SPF rabbits by fecal-oral route. J. Med. Virol. 88:681-685, 2016. (c) 2015 Wiley Periodicals, Inc.
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