4.1 Article

Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a): high frequency of small size apolipoprotein(a) isoforms

期刊

JOURNAL OF MEDICAL PRIMATOLOGY
卷 44, 期 3, 页码 117-124

出版社

WILEY-BLACKWELL
DOI: 10.1111/jmp.12160

关键词

apo(a) phenotype; K4 repeat; non-human primate; Old World monkey

资金

  1. UC Davis Clinical and Translational Science Center (NIH) [TR000002, RR024146]
  2. NIH National Heart, Lung, and Blood Institute (NHLBI) [HL062705, HL085794]
  3. California National Primate Research Center [OD011107]
  4. UC Davis CTSC Highly Innovative Pilot Award
  5. Mentored Clinical and Population Research Program Award from the American Heart Association [14CRP17930014]
  6. Building Interdisciplinary Research Careers in Women's Health/K12 Training Program [NIH 2K12HD051958]

向作者/读者索取更多资源

BackgroundLevels of lipoprotein(a), Lp(a), a genetically regulated independent cardiovascular risk factor present in humans and Old World monkeys, are impacted by the apolipoprotein(a), apo(a), gene. Allele-specific apo(a) levels, taking both the apo(a) genotypic and phenotypic characteristics into account, are useful markers to determine atherosclerotic cardiovascular risk. MethodsWe determined (i) the genetic variability of apo(a), (ii) Lp(a) levels, and (iii) allele-specific apo(a) levels in rhesus monkeys (n=95). ResultsLp(a) levels differed substantially between animals (range: 4-247nmol/l) with a skewed distribution toward lower levels. Lp(a) and allele-specific apo(a) levels were inversely related to the number of apo(a) Kringle 4 (K4) repeats. The median apo(a) size was 23K4 repeats, and the prevalence of a small size apo(a) (22K4) was 43%. ConclusionsDistribution of Lp(a) and allele-specific apo(a) levels in rhesus monkeys reflected the corresponding human patterns, but with a high prevalence of smaller apo(a) sizes.

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