期刊
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
卷 59, 期 4, 页码 514-519出版社
WILEY
DOI: 10.1111/1754-9485.12305
关键词
head and neck cancer; inflammation; neutrophil-to-lymphocyte ratio; NLR; radiotherapy
IntroductionThe neutrophil-to-lymphocyte ratio (NLR) is an index of systemic inflammatory burden in malignancy. An elevated NLR has been associated with poor prognosis in a number of cancer sites. We investigated its role in a cohort of patients with locally advanced head and neck cancer. MethodsEligible patients had primary mucosal squamous cell carcinoma treated with chemoradiotherapy and a minimum follow-up of 12 months (unless deceased). NLR was analysed as <5 vs. 5 and above and below the median. The primary endpoint was overall survival (OS) and secondary endpoints metastasis free survival and locoregional relapse free survival. Actuarial Kaplan-Meier statistics and log rank test were used. Univariate analysis for age (continuous), Eastern Cooperative Oncology Group performance status (0 vs. 1), gender (male vs. female), smoking (yes vs. no), American Joint Committee on Cancer stage (III vs. IV) and NLR (<5 vs. 5 and <3.3 vs. 3.3) were performed. ResultsForty-six patients were included in this analysis. Median NLR was 3.3 (0.4-22.8). After a median follow-up of 34 months (13-47 months), the 2-year estimated OS, metastasis free survival and locoregional relapse free survival for NLR<5 vs. 5 were 89% vs. 61% (p=0.017), 84% vs. 64% (p=0.083) and 81% vs. 70% (p=0.17) respectively. On univariate analysis NLR5 (p=0.025), older age (p=0.01) and ECOG 1 (p=0.025) were significant for OS. ConclusionIn this cohort of locally advanced head and neck cancer patients treated with chemoradiotherapy, pre-treatment NLR5 was prognostic for mortality. Further studies are required to confirm these results and to assess the interaction with other prognostic factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据