期刊
COMMENTS ON INORGANIC CHEMISTRY
卷 34, 期 3-4, 页码 114-123出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02603594.2014.890099
关键词
bioinorganic; medicinal chemistry; DNA mismatch repair
资金
- NIH [GM33309]
- NSF
- Moore Foundation of the Caltech Chemistry Signaling Center
Classical chemotherapeutics, such as cisplatin and its analogues, have been highly successful in the clinic, yet improvements can certainly be made, given the significant side effects associated with the killing of healthy cells. Recent advances in the field of chemotherapy include the development of targeted anticancer agents, compounds that are directed towards a specific biomarker of cancer, with the hopes that such targeted therapies might have reduced side effects given their greater selectivity. Here we discuss several transition metal complexes that are tailored towards various biomolecules associated with cancer. Most notably, the success of rhodium metalloinsertors, which specifically bind to nucleic acid base mismatches in DNA, highlight the enormous potential of this exciting new strategy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据