期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 116, 期 -, 页码 739-744出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.12.010
关键词
Aggregation-induced emission; Polyethylene polyamine; Anhydride ring-opening polymerization; Cross-linked fluorescent organic nanoparticles; Cell imaging
资金
- National Science Foundation of China [21134004, 21201108, 51363016]
- National 973 Project [2011CB935700]
- China Postdoctoral Science Foundation [2012M520243, 2013T60100, 2012M520388, 2013T60178]
An aggregation induced emission dye (RNH2) with two amino end-groups was facilely incorporated into stable cross-linked fluorescent organic nanoparticles via room temperature anhydride ring-opening polymerization and consecutive cross-linking with polyethylene polyamine. Thus obtained RO-OA-PEPA FONs were characterized by a series of techniques including H-1 nuclear magnetic resonance, Fourier transform infrared spectroscopy, UV-vis absorption spectrum, fluorescent spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of RO-OA-PEPA FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high-water dispersibility, strong red fluorescence, stable uniform morphology (100-200 nm) and excellent biocompatibility, making them promising for cell imaging application. (C) 2013 Elsevier B.V. All rights reserved.
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