期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 122, 期 -, 页码 404-413出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.07.014
关键词
Albumin; Drug delivery; Emulsion; Erosion; Microparticles; Drug release kinetics
资金
- CAPES
- CAPES/PNPD
- CNPq
- INOMAT
- Fundacao Araucaria-Brasil
- FCT/CAPES [329/13]
Albumin (BSA) microparticles were developed as a biotechnological alternative for drug delivery. Vitamin B-12 (Vit-B-12) was used as a model drug. The microparticles were obtained from maleic anhydride-functionalized BSA and N',N'-dimethylacrylamide (DMAAm) in a W/O emulsion without and with PVA. The microparticles produced at 15 min of stirring without PVA showed the best results in terms of size, homogeneity, and sphericity. In such a case, BSA played a role as a surface active agent, replacing PVA. For longer stirring times, BSA was unable to act as an emulsifier. These microparticles showed an uncommon release profile, consisting of a two-step release mechanism, at the pH range studied. Considering that a two-step release mechanism is occurring, the experimental data were adjusted by applying modified power law and Weibull equations in order to describe release mechanism n and release rate constant k, respectively. Each one of the release stages was related to a specific value of n and k. The second stage was driven by a super case II transport mechanism, as a result of diffusion, macromolecular relaxation, and erosion. A third model, described by Hixson-Crowell, confirmed the erosion mechanism. Vit-B-12 diffusion kinetics in aqueous solutions (i.e., without the microparticles) follows a one-step process, being k dependent on the pH, confirming that the two-step release mechanism is a characteristic profile of the developed microparticles. The microparticles released only 2.70% of their initial drug load at pH 2, and 58.53% at pH 10. (C) 2014 Elsevier B.V. All rights reserved.
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