期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 123, 期 -, 页码 53-60出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.07.050
关键词
Microencapsulation; Spray drying; Diffusion; Segregation
资金
- Alexander von Humboldt Foundation, Germany
Segregation of the protein bovine serum albumin (BSA) and lactose in thin aqueous films during drying was investigated by examining the composition of the dried films using inverse micro Raman spectroscopy (IMRS) and X-ray photoelectron spectroscopy (XPS) sputter-depth profiling. The composition was uniform through the thickness of the dried films except within a 10 nm region at the exposed surface where BSA had accumulated, most likely due to its surface activity. The thickness of the BSA layer was similar to the diameter of a BSA molecule, which suggests that a single monolayer of BSA adsorbed at the exposed surface. The BSA surface concentration of the dried films was constant over a wide range of BSA bulk concentrations, indicating that the aqueous surface became saturated with BSA during drying. The BSA surface layer of order 10 nm was significantly thinner than the film thickness of order 10 pm, which implies that BSA formed a surface coating rather than a shell, and thus lent no structural rigidity to the film. (C) 2014 Elsevier B.V. All rights reserved.
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