期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 124, 期 -, 页码 69-79出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2014.08.009
关键词
Polymer brushes; Biomaterials-surface engineering; Blood coagulation; Complement activation; Non-fouling surfaces; Antimicrobial surfaces
资金
- Canadian Institutes of Health Research (CIHR)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Health Canada/Canadian Blood Services graduate fellowship
- China Scholarship Council
- NSERC CREATE NCPRM
- Michael Smith Foundation for Health Research (MSFHR) Career Investigator Scholar Award
Undesirable host response is responsible for the surface induced thrombus generation, activation of the complement system and the inflammatory reactions by the blood-contacting biomaterials. The surface interaction of biomaterials with different blood components is thought to be the critical factor that dictates the host response to biomaterials. Surface engineering can be utilized as a method to enhance the biocompatibility and tailor the biological response to biomaterials. This review provides a brief account of various polymer brush based approaches used for biomaterials surface modification, both passive and bioactive, to make the material surfaces biocompatible and antibacterial. Initially we discuss the utilization of polymer brushes with different structure and chemistry as a novel strategy to design the surface non-fouling that passively prevent the subsequent biological responses. Further we explore the utility of different bioactive agents including peptides, carbohydrates and proteins which can be conjugated the polymer brush to make the surface actively interact with the body and modulate the host response. A number of such avenues have also been explored in this review. (C) 2014 Elsevier B.V. All rights reserved.
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