期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 116, 期 -, 页码 627-632出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2013.10.032
关键词
9-nitro-20(s)-camptothecin; Micelle; Drug delivery; Cytotoxicity; Cellular uptake
资金
- National Basic Research Program of China (National 973 program) [2011CB606206]
- National Science Foundation of China (NSFC) [31170921, 50830105, 51133004]
- National Science Foundation for Excellent Young Scholars [51222304]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1163]
The aim of this study was to develop a new polymeric micelle delivery system for antitumor drugs. An amphiphile of methoxypoly(ethylene glycol)-histidine-di(cinnamic acid) (PEGHC) with a small lipophilic moiety instead of a hydrophobic biodegradable polymer chain was synthesized and characterized. The PEGHC self-assembled into micelles. The critical micelle concentration (CMC) was tested. 9-Nitro-20(s)-camptothecin (9-NC) was used as a model drug for encapsulation. The size and morphology of both blank and 9-NC loaded micelles were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The release profile of 9-NC loaded micelles was studied. HepG2 liver cancer cells were incubated with the drug-loaded micelles to investigate the in vitro anticancer efficiency. The results showed that the 9-NC loaded micelles exhibited high accumulated release rate (>85%) and efficient in vitro anticancer activity. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据