Preparation and characterization of Paliperidone loaded solid lipid nanoparticles

Solid lipid nanoparticles were prepared and studied for the possibility of entrapment of Paliperidone (PPN) an antipsychotic drug that can be used for the treatment of schizophrenia. Here we report the preparation of Paliperidone loaded solid lipid particles (SLNs) with Capmul GMS 50K as lipid vehicle. SLNs were stabilized by a surfactant namely sodium deoxycholate which can also act as permeability enhancer. Final size of SLNs produced were approximately 200 nm which was confirmed by dynamic light scattering (DLS), atomic force microscopy (AFM) and transmission electron microscopy (TEM). SLNs appeared spherical in TEM images while dough nut like shape was observed by AFM. The entrapment efficiency of this system was found to be 55% with 4.15% of drug loading in lipid matrix. Structural characterization of SLNs by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD) and differential scanning calorimetric (DSC) analysis revealed that, there was no interaction of PPN with lipid and PPN was well dispersed in the lipid matrix without any crystallization. (c) 2012 Elsevier B.V. All rights reserved.