期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 110, 期 -, 页码 51-58出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.04.019
关键词
Feathers; Proteins; Graft polymerization; Films; Tissue engineering scaffolds
资金
- Agricultural Research Division at the University of Nebraska-Lincoln
- USDA Hatch Act
- Multistate Research Project [S1054, NEB 37-037]
- AATCC student research grant
- Program for Changjiang Scholars and Innovative Research Team in Jiangnan University [IRT1135]
- Scientific Support Program of Jiangsu Province [BE2011404]
- Graduate student innovation plan of Jiangsu Province [CX10B_222Z]
- Doctor Candidate Foundation of Jiangnan University [JUDCF10004]
- China Scholarship Council
This research demonstrated the feasibility of using bio-thermoplastics developed from chicken feathers grafted with acrylates and methacrylates as scaffolds for tissue engineering. Keratin, the major protein in feathers, is a highly crosslinked biopolymer that has been reported to be biocompatible. However, it is difficult to break the disulfide bonds and make keratin soluble to develop materials for tissue engineering and other medical applications. Previously, keratin extracted from feathers using alkaline hydrolysis has been made into scaffolds but with poor water stability and mechanical properties. In this study, thermoplastic films were compression molded from chicken feathers grafted with 6 different acrylate monomers. The influence of the concentration and structures of grafted monomers on grafting parameters and the tensile strength, water stability and cytocompatibility of grafted feathers compression molded into films were investigated. It was found that the grafted feather films were water stable and had good strength and better supported cell growth than poly(lactic acid) films. Grafted feathers demonstrated the potential to be used for fabrication of biomaterials for various biomedical applications. (c) 2013 Elsevier B.V. All rights reserved.
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