期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 105, 期 -, 页码 75-80出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2012.12.041
关键词
Halloysite; 5-ASA; Drug release kinetics; Inorganic carrier materials
资金
- Spanish project of the Ministerio de Ciencia e Innovacion (MICINN) [CGL2010-16369]
- Andalusian group [CTS946]
This paper investigates desorption of 5-aminosalicilyc acid (5-ASA) adsorbed onto halloysite (HL). Desorption isotherms were fitted according to kinetic laws obtained considering release of 5-ASA from HL as the phase of desorption of the previously adsorbed drug molecules both inside the nanotubes of HL as onto the surface of clay particles and/or in the inter-particle spaces of their aggregates [28]. Desorption isotherms has been also fitted with other equations frequently used in drug release kinetics studies. The best fitting corresponded to the kinetic model proposed; in agreement with the results of adsorption [28]. (C) 2013 Elsevier BM. All rights reserved.
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