期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 103, 期 -, 页码 182-188出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2012.10.016
关键词
Fast-dissolving drug delivery systems; Burst release; Electrospinning; PVA
资金
- H.C. Orsted DTU post-doc grant
- Danish Strategic Research Council [DSF-10-93456]
- FENAMI Project
- Jiangsu province innovation team in Colleges and Universities [Sue [2009]10]
Fast-dissolving drug delivery systems were prepared by electrospinning using polyvinyl alcohol (PVA) as the filament-forming polymer and drug carrier. Caffeine and riboflavin were used as the model drugs. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and X-ray diffraction were applied to investigate the physicochemical properties of electrospun nanofibers. The SEM images showed that nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm. Pharmacotechnical tests showed that PVA/caffeine and PVA/riboflavin nanofibrous mats had almost the same dissolution time (about 1.5 s) and wetting time (about 4.5 s). The release measurements indicated that drugs can be released in a burst manner (caffeine to an extent of 100% and riboflavin to an extent of 40% within 60 s) from the PVA nanofibrous matrices. (c) 2012 Elsevier B.V. All rights reserved.
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