期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 111, 期 -, 页码 188-202出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2013.05.022
关键词
Biomaterials; Composites; Graphene oxide (GO); Hemocompatibility; In vitro; In vivo
资金
- FEDER, through Programa Operacional Factores de Competitividade - COMPETE
- FCT - Fundacao para a Ciencia e a Tecnologia [PTDC/EME-PME/114808/2009, SFRH/BPD/63722/2009, SFRH/BD/86974/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/86974/2012, PTDC/EME-PME/114808/2009] Funding Source: FCT
Graphene-based materials (GBMs) have broad potential applications in biomedical engineering and biotechnology. However, existing studies regarding biological effects of GBMs often present contradictory or inconclusive results. This work presents a review of published data in order to provide a critical overview of the state of the art. Firstly, the distinct physical-chemical nature of the GBMs available is clarified, as well as the production methods involved. The review then discusses the available in vitro (with bacterial and mammalian cells) and in vivo studies concerning evaluation of GBMs biocompatibility, as well as existing hemocompatibility studies. The biocompatibility issues concerning composite materials that incorporate GBMs are addressed in a separate section, since encapsulation in a polymer matrix modifies biological interactions. The most pertinent questions that should be addressed in future works are also emphasized. (C) 2013 Elsevier B.V. All rights reserved.
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