Tetraphenylethene-based aggregation-induced emission fluorescent organic nanoparticles: Facile preparation and cell imaging application

Tetraphenylethene-based (TPE) aggregation-induced emission fluorescent organic nanoparticles (FONs) were facilely prepared via Schiff base condensation with epsilon-polylysine (Ply) and subsequent reduction to form stable C-N covalent bond. Thus obtained TPE-Ply FONs were characterized by a series of techniques including fluorescent spectroscopy, Fourier transform infrared spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of TPE-Ply FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, intense fluorescence, uniform morphology (100-200 nm) and excellent biocompatibility, making them promising for cell imaging application. (C) 2013 Elsevier B.V. All rights reserved.