期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 103, 期 -, 页码 52-58出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2012.10.025
关键词
Carboxybetaine; Zwitterions; ARGET-ATRP; Blood compatibility; Cellulose
资金
- Scientific Research Activate Funding of Nanjing Normal University [2011103XGQ0055]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [11KJD430003, 10KJA430026]
- National Natural Science Foundation of China [21274063]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Perspective Research Foundation of Production Study and Research Alliance of Jiangsu Province of China [BY2011109]
Grafting-from has proven to be a very effective way to create high grafting densities and well-controlled polymer chains on different kinds of surfaces. In this work, we aim to graft zwitterionic brush from cellulose membrane (CM) via ARGET-ATRP (Activator Regenerated by Electron Transfer ATRP) method indirectly for blood compatibility improvement. Characterization of the CM substrates before and after modification was carried out by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), water contact angle measurements, X-ray photoelectron spectroscopy analysis, and atomic force microscopy, respectively. The results demonstrated zwitterionic brushes were successfully grafted on the CM surfaces, and the content of the grafted layer increased gradually with the polymerization time. The platelet adhesion, hemolytic test and plasma protein adsorption results indicated the cellulose membrane had significantly excellent blood compatibility featured on lower platelet adhesion and protein adsorption without causing hemolysis. The functionalized cellulose substrate could have a great potential usage for biomedical applications. (c) 2012 Elsevier B.V. All rights reserved.
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