期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 106, 期 -, 页码 60-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.01.032
关键词
Graphene oxide; Fe3O4 nanoparticles; Folic acid; Chitosan; Dual-targeted drug nanocarrier
资金
- National Natural Science Foundation of China [20975056, 21275082, 81102411]
- Natural Science Foundation of Shandong [ZR2011BZ004, ZR2011BQ005]
- JSPS Japan [21111140014]
- NSFC China [21111140014]
- State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS1110]
- National Key Basic Research Development Program of China (973 special preliminary study plan, grant) [2012CB722705]
A novel triple functionalized drug delivery system was synthesized by encapsulation of superparamagnetic graphene oxide (GO) and doxorubicin (DOX) with folic acid (FA) conjugated chitosan (CHI). The carrier exhibited a high loading efficiency (0.98 mg/mg), a high saturation magnetization (10.5 emu/g) and a prolonged release rate. A real-time monitoring method on the drug release from graphene oxide (GO) was reported using DOX as the model drug. The release mechanism of DOX at different pH was investigated via monitoring the time dependency of the accumulative drug release. Results show that the drug release of DOX was pH sensitive as observed at pH 5.3 and pH 7.4 PBS solutions, the lower pH values lead to weaker hydrogen bonds and degradation of CHI, and thus result in a higher release rate of DOX. Especially, this system could be applied as a dual-targeted drug nanocarrier by combined biological (active) and magnetical (passive) targeting capabilities. Our research suggests that a novel triple functionalized, pH-responsive nanocarrier for anticancer drug has been synthesized. (C) 2013 Elsevier B.V. All rights reserved.
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