期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 107, 期 -, 页码 220-226出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2013.02.007
关键词
Silica-coated TiO2 nanoparticles; Silica coating; TiO2 nanoparticles; Photo-killing agent; Photodynamic therapy
Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy. In this paper, core shell structured titanium dioxide silica (TiO2-SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicity and photo-killing ability of the TiO2 nanoparticles was investigated. Silica coating reduced the photocatalytic reactivity but improved the cytocompatibility of the TiO2 nanoparticles. This effect was amplified with increasing silica shell thickness. When the silica thickness was about 5.5 nm, the coated TiO2 not only retained a high level photodynamic reactivity, comparable to the non-coated TiO2 nanoparticles, but also demonstrated an improved cell compatibility and effective photo-killing ability upon the mouse fibroblast cells (L929). (C) 2013 Elsevier B.V. All rights reserved.
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