期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 103, 期 -, 页码 275-282出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2012.10.038
关键词
Itraconazole; Tea tree oil; MTT assay; Pseudo ternary phase diagram; Mucoadhesion
资金
- University grants commission, New Delhi
The singular aim of the proposed work is the development of a synergistic thermosensitive gel for vaginal application in subjects prone to recurrent vaginal candidiasis and other microbial infections. The dual loading of Itraconazole and tea tree oil in a single formulation seems promising as it would elaborate the microbial coverage. Despite being low solubility of Itraconazole in tea tree oil, a homogeneous, transparent and stable solution of both was created by co-solvency using chloroform. Complete removal of chloroform was authenticated by GC-MS and the oil solution was used in the development of nanoemulsion which was further translated into a gel bearing thermosensitive properties. In vitro analyses (MTT assay, viscosity measurement, mucoadhesion, ex vivo permeation, etc.) and in vivo studies (bioadhesion, irritation potential and fungal clearance kinetics in rat model) of final formulation were carried out to establish its potential for further clinical evaluation. (c) 2012 Elsevier B.V. All rights reserved.
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