期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 94, 期 -, 页码 107-113出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2012.01.038
关键词
Adhesion of cells; Adsorption of proteins; Anti-biofouling; Graft of zwitterionic polymer; Zwitterionic copolymer layer
资金
- Japan Society for the Promotion of Science (JSPS) [22350101]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Tokyo, Japan [20106007]
- Osaka Organic Chemical Industry
- Grants-in-Aid for Scientific Research [20106007, 22350101] Funding Source: KAKEN
A random copolymer of zwitterionic monomer, carboxymethylbetaine (CMB), and 3-methacryloyloxypropyl trimethoxysilane was prepared in ethanol using 2,2'-azobisisobutyronitrile as initiator. The incubation of ethanol solution of the copolymer with a glass plate gave a layer of the copolymer with a thickness of about 2-3 nm. The copolymer-modified glass substrate became highly hydrophilic upon immersion in water, and showed a resistance against non-specific adsorption of proteins, and the degree of resistance increased with the content of CMB residues in the copolymer and leveled off. The adhesion of various cells to the glass substrate was also strongly suppressed by the surface modification with the copolymer layer. Further introduction of PolyCMB graft chains on the surface of the layer enhanced the suppression of cell adhesion due to the steric hindrance for the cells to approach the layer. The usefulness of the combination of zwitterionic polymer layer and graft chains to afford anti-biofouling properties to a solid surface of metal oxides was shown. (C) 2012 Elsevier B.V. All rights reserved.
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