期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 88, 期 1, 页码 315-324出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2011.07.008
关键词
Surface modification; Polyethersulfone membrane; mPEG-PU-mPEG copolymer; Anti-protein-fouling; Platelet adhesion; Cytocompatibility
资金
- National Natural Science Foundation of China [50973070, 51073105, 30900691]
- Sichuan Youth Science and Technology Foundation [08ZQ026-038]
The surface of polyethersulfone (PES) membrane was modified by blending triblock copolymers of methoxyl poly(ethylene glycol)-polyurethane-methoxyl poly(ethylene glycol) (mPEG-PU-mPEG), which were synthesized through solution polymerization with mPEG Mns of 500 and 2000, respectively. The PES and PES/mPEG-PU-mPEG blended membranes were prepared through spin coating coupled with liquid-liquid phase separation. FTIR and H-1 NMR analysis confirmed that the triblock copolymers were successfully synthesized. The functional groups and morphologies of the membranes were studied by ATR-FTIR and SEM, respectively. It was found that the triblock copolymers were blended into PES membranes successfully, and the morphologies of the blended membranes were somewhat different from PES membrane. The water contact angles and platelet adhesion were decreased after blending mPEG-Ph-mPEG into PES membranes. Meanwhile, the activated partial thromboplastin time (APTT) for the blended membranes increased. The anti-protein-fouling property and permeation property of the blended membranes improved obviously. SEM observation and 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (KIT) assay proved the surfaces of the blended membranes promoted human hepatocytes adhesion and proliferation better than PES membrane. (C) 2011 Elsevier B.V. All rights reserved.
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