期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 76, 期 1, 页码 286-291出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2009.11.006
关键词
Cationic solid lipid nanoparticles; Human brain microvascular endothelial cells; Electrical interaction energy; Electrophoretic mobility; Zeta potential
资金
- National Science Council of the Republic of China
This study analyzes the effects of Tween 80 and Span 20 on the electrical interaction between cationic solid lipid nanoparticles (CSLNs) and human brain microvascular endothelial cells (HBMECs). Electrophoretic mobility, zeta potential and fixed charge density of CSLNs and HBMECs with uptake of CSLNs were also investigated. The results revealed that a higher molar ratio of Tween 80 yielded smaller CSLNs, higher charge of CSLNs and larger electrical attraction energy between CSLNs and HBMECs. On the contrary, a decrease in the molar ratio of Tween 80 enhanced the absolute Values of electrophoretic mobility and zeta potential of CSLNs-incorporating HBMECs. In addition, a higher concentration of CSLNs in the dispersion medium led to lower charge of CSLNs-incorporating HBMECs. An increased concentration of glutamate from I to 2 mg/mL enhanced the absolute values of electrophoretic properties of CSLNs-incorporating HBMECs. In the case of increasing concentration of glutamate, pure Tween 80 was stronger in charge enhancement than pure Span 20. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据