期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 78, 期 2, 页码 259-265出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2010.03.012
关键词
Protein complex/aggregate; Cancer biomarker; Gold nanoparticle; Immunoassay; Dynamic light scattering
资金
- Florida Department of Health, Bankhead-Coley Foundation
- World Gold Council-GROW Program
- Natural Science Foundation of China
Protein-protein interactions and protein complex/aggregate formation play an essential role in almost all biological functions and activities. Through a nanoparticle aggregation immunoassay, we discovered that some proteins are substantially more complexed/aggregated in cancer tissues than normal tissues. This study examined four biomarkers proteins, CA125, CEA (carcinoembryonic antigen), CA19-9 and PAP (prostatic acid phosphatase) in ovarian, colon and prostate tissue lysates. The most exciting results were observed from the PAP assay of prostate tissues: prostate cancer can be clearly distinguished from normal prostate and prostate with benign conditions such as BPH (benign prostate hyperplasia) based on the complex/aggregation level of PAP in prostate tissue lysates. The complex/aggregate level of a protein can be potential biomarkers for cancer detection and diagnosis. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据