期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 71, 期 1, 页码 13-18出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2008.12.040
关键词
Hydrogels; N-Isopropylacrylamide; Dextran; Temperature-sensitivity; Cell culture
资金
- National Nature Science Foundation of China [20574051]
- Specialized Research Fund for the Doctoral Program of Higher Education [20050058001]
A series of poly(NIPAAm-co-GMA-Dex) hydrogels were synthesized from glycidyl methacrylate-derivatized dextran (GMA-Dex) and N-isopropylacrylamide (NIPAAm) in aqueous solution. The swelling properties, cell culture and detachment behaviors of these hydrogels were investigated. It has found that poly(NIPAAm-co-GMA-Dex) hydrogels are not only sensitive to temperature in deionized water and Dulbecco's modified eagle medium (DMEM) (10% FBS), but also exhibit good biocompatibility. In addition, L929 cells were found to detach from the hydrogel surface naturally without affecting the function of L929 by controlling environmental temperature. (C) 2009 Elsevier B.V. All rights reserved.
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