期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 71, 期 2, 页码 268-274出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2009.02.014
关键词
Phosphorylcholine; Chitosan; Hemocompatibility; Surface modification; Contact angle; XPS
资金
- National Natural Science Foundation of China [20774073]
- Foundation of the State Key Laboratory of Polymer Physics & Polymer Chemistry [200605]
A novel strategy has been developed to improve the hemocompatibility of chitosan surface by cell outer membrane mimetic structure able to reduce protein adsorption and cell adhesion. Phosphorylcholine dichloride was synthesized and grafted onto a glutaraldehyde-cross-linked chitosan (CS-GA) film surface to prepare phosphorylcholine-coated CS-GA film (CS-GA-PC) through a heterogeneous reaction process. The spectroscopic and contact angle characterization show that a cell outer membrane mimetic structure was formed on the cross-linked chitosan surface, and the significantly improved hemocompatibility of the modified surface was shown by a suppression of 94% on platelet adhesion, a suppression of 60-70% for bovine plasma fibrinogen and bovine serum albumin adsorptions. These results demonstrated that this cell outer membrane mimetic surface modification with phosphorylcholine dichloride is a promising strategy to improve the hemocompatibility of chitosan. (C) 2009 Elsevier BY. All rights reserved.
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