Mesenchymal cell response to nanosized biphasic calcium phosphate composites

Biphasic calcium phosphate nanoparticles comprising both hydroxyapatite (HA) and P polymorph of tricalcium phosphate (beta-TCP) have been synthesized together by a polymer matrix mediated process. The process, based on in situ mineralization of poly (vinyl alcohol), exerts a good control over the morphological features of biphasic nanoparticles. By controlling the reaction chemistry (Ca:P ratios), nanobioceramic particles having three different HA/beta-TCP ratios of 50:50, 55:45 and 60:40 respectively. As the two constituents of biphasic system (HA and beta-TCP) facilitate series of signaling cascades in osteoblast division and differentiation, the adhesion and differentiation properties of mesenchymal cells (MSCs) derived from bone marrow has been studied. (C) 2009 Elsevier B.V. All rights reserved.