期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 72, 期 2, 页码 201-207出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2009.04.004
关键词
Human brain-microvascular endothelial cells; Solid lipid nanoparticle; L-arginine; Electromagnetic field; Charge
资金
- National Science Council of the Republic of China
Electrokinetic and electrostatic properties of human brain-microvascular endothelial cells (HBMECs) with the uptake Of L-arginine (Arg)-modified solid lipid nanoparticles (RSLNs) were investigated. The exposure of these HBMECs to radiofrequency electromagnetic field (EMF) was also considered. As compared with the original culture of HBMECs, the uptake of the biomimetic RSLNs induced smaller absolute values of electrophoretic mobility, zeta potential, Donnan potential, and fixed charge density. In addition, an increase in the coverage fraction of Arg on the external layers of the RSLNs reduced the electrical characteristics of HBMECs. An increase in the power of EMF also decreased the charge of RSLNs-incorporating HBMECs. On the contrary, softness of HBMECs was enhanced by an increased coverage fraction of Arg and an increased power of EMF. Electrophysiology of HBMECs can be efficiently mediated by the novel RSLNs and exposure to EMF through fluctuation and redistribution of the membrane charge. (C) 2009 Elsevier B.V. All rights reserved.
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